Platelet Factor 4 (PF4)

Platelet factor 4 (PF4), a 30 kDa heparin-binding protein stored in platelets. It is secreted by stimulated platelets and its plasma biological half-life is <5 minutes. The primary function of PF4 is to neutralize the anticoagulant effect of heparin. Heparin neutralization occurs by the binding of PF4 to heparin at sites that are different from heparin's antithrombin binding site. Heparin therapy induces the release of PF4 from endothelial cells. Increased levels of PF4 are found in a variety of clinical states including inflammatory or infectious diseases. Decreased PF4 levels are seen in patients with grey platelet syndrome, a type of platelet storage defect. Accelerated platelet turnover can result in PF4 levels 10 times normal.


Product:
PF4
 
Cat No:
P539-3
 
Specification:
>95% pure
 
Source:
Human blood
 
Min Pk:
100 µg
 
Presentation:
TRIS / NaCl
 
Storage:
<-15°C
 
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