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Human Chorionic Gonadtropin Monoclonal Antibody (HCG mAb)
Human Chorionic Gonadotropin (hCG) is a 39.5 kDa hormone produced during pregnancy by cells of the placenta. It is comprised of two subunits, one alpha and one beta. The alpha subunit is nearly identical to that of follicle stimulating hormone (FSH), luteinizing hormone (LH) and thyroid stimulating hormone (TSH). hCG is produced during pregnancy, where levels rise dramatically around 10 days after fertilization of the egg. hCG levels then double every two days for the first 60 days of pregnancy.
Within medical diagnostics, hCG is most commonly utilized in home pregnancy tests. hCG can be detected as early as 6 days after conception, and peaks between 56 – 68 days after conception. Both regular hCG and hyperglycosylated hCG are measured, where hyperglycosylated hCG is the principle molecule within the first two weeks. Urine based pregnancy test kits can have detection limits as low as 6.3IU / L. hCG is also measured during the treatment of patients suffering germinal cell tumors.
Scipac offer high affinity monoclonal hCG antibodies that can be used for alpha-beta or beta-beta ELISA development and in other applications. SCIPAC antibodies are tested in both western blot and ELISA assay.
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